Five years after the rampage of Edward Hyde, a new, refined version of the serum that created him became available in London. Dr. John Utterson, a friend of Dr. Henry Jekyll, took up the study of his fallen comrade, eventually creating the high society sensation that was the drug, Liberation.

Liberation was an immediate hit among the repressed upper classes of Victorian London, an intoxicant (and a mild steroid) that freed one from the shackles of social expectation – and lead its users into debaucheries of all kinds. But there were a few complications. Edward Hyde was not dead, but rather imprisoned by the police, with Utterson as his jailer. And the serum, like its predecessor, had a vital ingredient that was hard to come by legally: human adrenal glands. In fact, it was the need for these that drove Utterson to commit the series of murders and mutilations that became known as the crimes of Jack the Ripper.

Edward Hyde and Inspector Thomas Adye tracked Utterson to his lair and killed him in the ensuing confrontation. Also destroyed were all remaining supplies of Liberation, Utterson’s notes for making more and Mr. Hyde – although it later turned out that he had faked his death, after he spent the next few weeks murdering Utterson’s pushers.