A derivative of Venom, Titan combines that drug with other chemicals derived from the plants of Poison Ivy. Created by Dr Penelope Young, it was primarily used by the Joker in one of his periodic takeovers of Arkham Asylum. The Joker dosed numerous henchmen with Titan before finally taking it himself. Batman defeated them all handily anyway. Later, the Dark Knight joined forces with fellow former Venom addict Bane to destroy all remaining supplies of Titan, although it appears that Harley Quinn may still have some.
The effects of Titan are an exaggerated version of those of Venom, including massive and swift increase of musculature and strength, but also mental devolution into a berserker state. In addition, the effects of Titan are disfiguring, leading to distorted facial features and exposed spinal columns among users – the effect are also permanent.