Orpheus

Orpheus is a vampire drug, a mystical opiate which is taken in with the blood of those they feed from – the humans typically inject the drug into their bloodstreams before the feeding.
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Buffy the Vampire Slayer and Delta Green

Another fairly natural fit: Buffy’s shadowy government manipulators and those of Delta Green work very well together. After all, both groups fight the monsters in the shadows while struggling not to become more like them, and both groups prefer to operate in secrecy.
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Calynthia Powder

Calynthia Powder is a bright purple colour. As a powder, it can be mixed into liquids and ingested, such as water or blood.
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The Implied Buffyverse

There are certain works that many would consider to more crossovers with the Buffyverse, but personally, I think of these three as implicit within it. Each of them has good reasons for being considered canonical in-universe, despite not being officially a part of it:
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Calendula

Calendula is actually a real substance: it’s a herb derived from the plant of that name. The plant is a small yellow flower that grows across Mediterranean Europe and the Middle East, from the Azores to Iran.
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1996 – Jonathan Melvoin dies of a drug overdose

Jonathan Melvoin was the brother of Susannah and Wendy Melvoin, who were members of Prince’s New Power Generation. He had worked with Prince, and also as a member of the Dickies. At the time of his death, he was touring with the Smashing Pumpkins – Melvoin was a skilled keyboardist.

His death was caused by a heroin overdose, not his first. Melvoin was survived by a wife and child. The Smashing Pumpkins, who had already fired Melvoin for his drug use at the time of his death, were not invited to his funeral.

Referenced in:

Jonathon – Wendy & Lisa
Angel – Sarah McLachlan
The Love We Make – Prince

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